Evaluation of the preventive effect of the total aqueous extract of Lippia multiflora Moldenke leaves on anthropometric parameters in rats made obese by a hypercaloric diet

Kassim Dosso || Dago Désiré Koudou || Mea Adélaïde Nadia Blahi

Volume 15, Issue 5 2025

Abstract:

Background : Obesity has become a serious public health problem, with modern treatment being lengthy and costly, and therefore often inaccessible to all patients. Traditional medicine therefore offers an alternative for lowincome populations. Objectives : The objective of this study was to evaluate the effect of Lippia multiflora aqueous extract on obesity prevention through anthropometric parameters. Methods: We therefore administered the aqueous extract of this plant at doses of 200 and 400 mg/kg bw to rats made obese by a high-calorie diet composed of sucrose and paraffin oil for 28 days. Results: The extract at these different doses showed a decrease in anthropometric parameters (body mass, weight gain, body mass index, and abdominal circumference). This decrease was significant for body mass, weight gain, and abdominal circumference. The extract also restored the relative masses of organs (liver, heart, kidneys, visceral adipose tissue, and abdominal subcutaneous tissue) disrupted by feeding a high-calorie diet in rats at doses of 200 and 400 mg/kg bw. Conclusion : In summary, Lippia multiflora possesses anti-obesity effects, allowing it to prevent the onset of obesity due to a high-calorie diet.

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