Effects of synergist ethacrynic acid (ETAA or EA) on dichlorodiphenyltrichloroethane (DDT) tolerance in Culex quinquefasciatus Say larvae from Klouekanmè district in Couffo department in south-western Benin, West Africa

Nazaire Aïzoun

Volume 16, Issue 1 2026

Abstract:

Background: Mosquito control programs are now threatened by the selection of mosquito populations resistant to the chemical insecticides. Thus, alternative vector control methods are necessary. Material and Methods: Larvae and pupae were collected from April to July 2024 during the great rainy season in Klouekanmè district surveyed. Larval bioassays were performed on these collected Culex quinquefasciatus larvae using dichlorodiphenyltrichloroethane (DDT) as larvicide and ethacrynic acid (ETAA or EA) as enzyme inhibitor or synergist. Results: The results showed that glutathione S-transferases (GSTs) may play a role in Culex quinquefasciatus larvae resistance to DDT in Klouekanmey. Conclusion: Glutathione S-transferases played a role in Culex quinquefasciatus larvae tolerance to DDT in Couffo department in south-western Benin.

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